Leucoderma is particularly known by the presence of white patches which could be localized to smaller areas in the beginning. However, with the passage of time, the skin patches might get enlarged. Most of the major skin changes might become noticeable around the age of 10 to 30 years. Such skin color changes are more noticeable in people with darker skin complexions. Leucoderma has no cure, but homeopathic treatment help to stop or slow the process of colour loss and brings back some colour to the skin. The failure of melanocytes can be attributed to a disorder in which immune system attacks and destroys them. It can also be triggered by sunburn, stress, or exposure to industrial chemicals. People with Leucoderma are at risk of Social or psychological distress, loss of hearing, sunburn, and skin cancer, inflammation of the iris, and dry skin. The homeopathic treatment enhances the natural production of pigments and Leucoderma is considered as a manifestation of an inner disturbed state of the body. The patient is analyzed on mental, physical, and familial attributes. The homeopathy medication is then based on the results. Arsenic Sulph Falvus, Arsenic Album, Baryta Mur, and Baryta Carb are known to give good results in Leucoderma. Leucoderma is a chronic disorder and it takes a long time even with the best of the homeopathic treatment. Some effective homeopathy remedies are: 1) Calcarea Carb: This effective homeopathic medicine prescribed to patients of Leucoderma with milky white spots on skin. It is prescribed to free perspiration over the head, neck, and chest and persons with intolerance to cold weather. 2) Arsenic Album: Use this homeopathy medicine for white patches, It is a useful remedy for Leucoderma in persons prone to dry, rough skin. The skin complaint coupled with asthma is a strong contender for using homeopathic medicine Arsenic Album. 3) Sepia is prescribed for Leucoderma in persons showing unresponsive attitude towards family and life 4) Silicea: Homeopathic medicine for white spots on skin is prescribed for Leucoderma patients with pale and waxy skin, a tendency to excessive perspiration. If the main mind symptom is timidity and an under-confident nature, then Silicea is a good choice. It is known to work on patients who seem under-confident, fear public speaking. 5) Sulphur: Leucoderma treatment in homeopathy is possible using sulphur as it goes deep inside the basic root cause to exterminate the disease. The persons requiring homeopathic medicine Sulphur show a mind constantly occupied with various theories and plans due to which they suffer from mental fatigue and absent-mindedness. with milky white spots on skin. It is prescribed to free perspiration over the head, neck, and chest and persons with intolerance to cold weather.