Dr. Madhav's Nano homeopathy Kidney failure is caused by other health problems and when your kidneys lose the ability to sufficiently filter waste from your blood. The last stage of chronic kidney disease is kidney failure. It is also called end-stage renal disease or ESRD for short. The most common cause of ESRD is diabetes and high blood pressure is the second most common cause of ESRD other problems that can cause kidney failure Which involves genetic diseases such as paly cystic kidney disease autoimmune diseases such as lupus and IGA nephropathy. nephrotic syndrome and urinary tract problems.